Microsoft 365 Copilot security best practices include data loss prevention, sensitivity labels, Purview controls, least privilege access, third-party connector monitoring, eDiscovery, audit logs, and NIST 800-171 compliance to protect data and ensure compliance.

Before deploying Microsoft 365 Copilot, ensure strong identity management, data governance, Zero Trust security, compliance, tailored licensing, user training, prompt engineering, and secure collaboration policies to mitigate risks.